Inflammation can have a significant impact on the health and quality of life of the body. It is also the cause behind many chronic diseases and is currently a growing burden on global health care. So what is inflammation? What is the cause of inflammation?

In terms of standards, inflammation refers to the swelling on the finger, the red hot area, or the pain and swelling that is caused by the sprain of the ankle when we walk down the stairs. In these cases, the body inflammation is manifested. Very obvious and uncomfortable, but the body often protects the body from further damage by recruiting immune cells to hell infection or reacting to tissue damage.

When immune cells detect invading microbes or danger signals, they send a special set of chemicals that kill foreign invading pathogens, while other chemicals called cytokines recruit other immunity. As the cells enter the affected area, an increase in vascular permeability enhances the entry of immune cells into the site of injury. Therefore, tissue redness, swelling and pain may be caused by the influx of cells and body fluids. Of course, this may be the collateral damage caused by the body in response to inflammatory damage.

As the symptoms of inflammation weaken in a few days or weeks, our fingers and ankles return to normal; this is because the body's inflammation is proceduralally blocked; the chemicals released by the inflammatory cells of the inflammatory site can intentionally “ This battle "switched from the attack phase to the treatment phase, thus promoting the organization to return to normal. People usually take anti-inflammatory drugs, which may not interfere with the healing process of the wound, but it will reduce the side effects such as pain and swelling. Therefore, inflammation may be one of the oldest forms of defense in the body, which can quickly and effectively protect the health of the body in a variety of situations.

Which piece is wrong?

Failure to block the onset of inflammation in chronic diseases often results in some terrible and painful consequences for the body's weakness. Patients with rheumatoid arthritis or inflammatory bowel disease may agree. In these inflammatory diseases, the body's normal and reliable chemical control of inflammation is often interrupted, which means that inflammation will continue, rather than stop, if there is no important "off" signal, the body's immune cells will Will continue to release harmful chemicals, killing their own cells, even in the absence of any microbial pathogens.

Nowadays, we all know that in many cases and in the growing number of common chronic diseases, inflammation is released, modern society is full of inflammation, and we can easily find, for example, tobacco smoke, air pollution, food or water, organism microorganisms. Group, and some mental factors, such as stress.

Due to the environment and lifestyle, we are now living in a low level of inflammatory signaling environment, and at the same time we are constantly arming our body's immune system. Of course, this may be a silent threat that does not trigger Common symptoms of inflammation, but nevertheless, this complicates other possible disease processes. Aging reduces our control of inflammation in the body. Today, inflammation is thought to be the cause or complex cause of many diseases, such as diabetes, obesity, cancer, depression and heart disease.

What disease does inflammation cause?

Recently, studies have shown that inflammation may occur in the development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In a large-scale genetic study, researchers will suffer from Alzheimer's disease and not. A comparison of the diseased population revealed that many of the DNA changes that occur in the body's genes are directly related to the inflammatory pathway, suggesting some of the conditions that trigger or respond to inflammation.

In a study earlier this year, researchers found that the use of special drugs to reduce the body's inflammation may be able to effectively protect the body from heart attack, while also reducing the risk of lung cancer in smokers. There is a very complex relationship between inflammation and many cancers. Early activation of the inflammatory response may help immune cells kill cancer cells, and in the advanced stages inflammation can unintentionally help spread the cancer.

How do we deal with inflammation?

We often take steroids or anti-inflammatory drugs to suppress the occurrence of acute inflammation, such as ankle sprains; in chronic diseases, we need to know which part of the inflammation of Tonglu is enhanced or down-regulated at different stages of the disease. So we need to find a way to balance the body's immune response, rather than simply increasing or decreasing the response. Now researchers have discovered a number of normal regulatory tungs that can turn off or turn on inflammation, which may help researchers develop a variety of successful therapies as special inflammatory drugs for arthritis, inflammatory bowel disease and other diseases.

These therapies often use antibodies to target and block inflammatory mediators (cytokines), while also successfully inhibiting unwanted inflammatory reactions in some patients' bodies; recent researchers have A specific protein has been identified that can be targeted to develop patients with inflammatory bowel disease who are not responding to cytokine-targeted drugs. What makes researchers incredible is that in the latest research, researchers can uncover many of the mysteries of inflammation, which may help them effectively control the occurrence of multiple diseases and develop a variety of new therapies to treat these diseases.

A large number of experiments have proved that it is an important factor in inducing cancer in severe cases.

In addition, recent studies have shown that nanosilver and platinum have a strong elimination effect. Perhaps oral administration of nano-platinum in the future can help people reduce the side effects of inflammation.

Organized according to Bio Valley Information

Reference materials:

[1]Inflammation: Inflammasome-related ageing

Nat Rev Immunol https://www.nature.com/articles/nri.2017.3

[2]The role of inflammation in depression: from evolutionary imperative to modern treatment target

Nature Reviews Immunology 16, 22–34 (2016) doi:10.1038/nri.2015.5

[3]Genome-wide association studies in Alzheimer's disease: a review.

Curr Neurol Neurosci Rep. 2013 Oct;13(10):381. doi: 10.1007/s11910-013-0381-0

[4]Anti-inflammatory drug cuts risk of heart attack and lung cancer – but at what cost?

[5]Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

N Engl J Med 2017; 377:1119-1131September 21, 2017DOI: 10.1056/NEJMoa1707914

[6] Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

Nat Med. 2017 May;23(5):579-589. doi: 10.1038/nm.4307

[7]Explainer: what is inflammation and how does it cause disease?