Yongzheng Young believes that many people's dreams can effectively slow down the body's aging and maintain youth. Take a look at the following studies!

[1] Prev Med: The lazy move! High level of physical activity or can make you 9 years younger!

DOI: 10.1016/j.ypmed.2017.04.027

Despite a lot of efforts, no scientists can effectively stop human aging, and even anti-aging creams can't stop time old people. Recently, researchers from Brigham Young University have said through research that we may hope to slow down another kind of aging. , that is, aging inside the cell, but only if we are willing to sweat; related research published in the international magazine Preventive Medicine.

Researcher Tucker said that just because you are 40 years old doesn't mean you are 40 years old in biology. We all know that people are younger than their actual age, and the more we exercise, the more biological we have. The slower the aging process takes place; the researchers found that telomeres in the body cells of people who continued to perform high levels of physical activity were significantly longer than those in the meditation lifestyle and those with moderate levels of activity. Telomere is the protein cap-like structure at the end of the chromosome. It is directly related to age like the body clock of our body. When the cell divides once, we lose a small amount of telomeres, so as the body gets older, our end The grain will also get shorter and shorter.

Larry Tucker, a professor of sports science, found that telomeres in high-level sports populations have a nine-year biological aging advantage over telomeres in a sedentary population, which is seven years longer than the telomeres of moderately active populations. In order to become more active, women should take 30 minutes of jogging per day (40 minutes per day for men) and last every Friday. If you want to see the real difference in the body's slowing down of aging, it doesn't seem to be good to not participate in exercise, and we must always exercise regularly at high levels.

[2] Studies have found that anti-aging peptides can restore youthfulness

Anti-aging treatment may be a step closer; in a new study, the researchers revealed how a peptide destroys cells that play a role in aging, reverses skin loss, kidney damage, and mouse weakness.

This study describes how peptides block the level of protein called FOXO4 that increases senescent cells.

Aging cells accumulate with age, and studies have shown that they can act on the aging process by causing damage to adjacent cells and impairing tissue function.

By blocking FOXO4 with peptides, the research team has been able to restore programmed cell death or apoptosis in senescent cells.

Senior author Peter de Keizer is an aging researcher at the Erasmus University Medical Center in the Netherlands. "Only aging cells can cause this peptide to cause cell death."

[3] BMC Cell Biol: Revealing resveratrol analogues can restore aging cells to youth

Doi:10.1186/s12860-017-0147-7

In a new study, a research team led by Lorna Harries, a professor of molecular genetics at the University of Exeter in the UK, discovered a new way to rejuvenate inactive aging cells. Within a few hours of treatment, these senescent cells begin to divide and have longer telomeres. The results of the study were published in the BMC Cell Biology Journal on October 17, 2017, and the paper titled "Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence".

This finding is based on the earlier findings of the Harries team - when our age increases, a class of genes called splicing factors are gradually shut down. The Harries team, together with Professor Richard Faragher and Dr. Elizabeth Ostler from the University of Brighton in the UK, discovered that the use of compounds can reopen the splicing factor, making aging cells not only look younger, but also begin to behave more like young cells and begin to divide. .

These researchers added a compound called a resveratrol analog to cells cultured in vitro. These compounds cause the splicing factor to be gradually turned off as we age. Within a few hours, these cells look younger, begin to rejuvenate, behave like young cells and divide.

[4] Scientists decipher the process of aging, looking for a recipe for youthfulness

Human beings have always had beautiful illusions about youthfulness and longevity. From ancient times to now, stories about finding secret recipes for immortality have emerged endlessly. Even the great Alexander the Great is looking for a cure for time. In addition to our obsession with immortality, we don't really know how aging actually happened. Why do we get older, how do we get older, can we delay the process of aging? Fortunately, with the continuous development of technology, we now have more precise tools than ancient mythology. Scientists have invented an instrument that can predict the aging process based on mouse genomic activity and can be used to delay aging.

Aging is inevitable in both animals and humans, but the process of aging is not the same. Not only are different species complex and diverse, even the aging process of different organs is different. We don't know if the aging process is pre-set, part of the intrinsic circadian clock, or because of the side effects of “wear”.

Biologists divide age into two categories: one is the age of the creature, the age defined by the function of the various organs of the body; the actual age is the age determined by your date of birth. For example, a young man who is addicted to alcohol has a very "old" liver, but a healthy young person may have an aging liver. It is not clear what affects the biological age.

[5] Scientists find the "secret side" of immortality, and eternal youth is not a dream.

Researchers from the University of New South Wales have recently had a revolutionary discovery that could reverse human aging and improve DNA repair. The study, published in Science Today, points out that researchers have identified a key step in the molecular process that allows cells to repair damaged DNA.

In a laboratory mouse experiment to treat aging in mice due to aging and radiation, the study caught the attention of NASA, which they believe could help astronauts perform missions on Mars.

In fact, our cells are inherently rehabilitative, as long as they are sun-baked, however, this ability declines with age. Scientists have discovered that the metabolite NAD + naturally exists in every cell of our body and is responsible for mediating the interaction between proteins and proteins that control DNA repair.

[6] NeuroImage: Aerobic exercise or maintenance of brain size significantly improves aging caused by aging

DOI: 10.1016/j.neuroimage.2017.11.007

Recently, researchers from the University of Western Sydney and the University of Manchester have found that as we age, aerobic exercise can effectively improve the brain's memory function and maintain brain health, the relevant research published in the international magazine NeuroImage.

In the article, the researchers examined the effects of aerobic exercise on the hippocampus of the brain. The hippocampus is primarily responsible for brain memory and other brain functions. As the body ages, the health of the brain will gradually decline. After 40 years of age, the brain will shrink about 5% on average every ten years. After studying rats and mice, the researchers found that physical exercise can Increased the size of the animal's hippocampus, but so far researchers have not found consistent results in the human brain.

The investigators conducted a systematic review of 14 clinical trials in which the researchers performed brain scans of 737 individuals before and after aerobic exercise and in controlled conditions; participants included healthy adults and individuals with mild cognitive impairment ( For example, Alzheimer's disease, patients with clinical diagnosis of mental illness (including depression and schizophrenia), these participants range in age from 24 to 76 years, with an average age of 66 years.

[7] Food Chem: Eat more mushrooms or anti-aging to fight against cancer and neurodegenerative diseases

Doi:10.1016/j.foodchem.2017.04.109

Recently, researchers from the Pennsylvania State University found that mushrooms may contain abnormally high levels of two antioxidants, and antioxidants are thought to help fight the body's aging and promote health. Related research was published in the international magazine Food Chemistry.

In this study, the researchers found that mushrooms contain higher levels of ergothione and glutathione, both of which are important antioxidants that vary widely in different types of mushrooms. There is no doubt that mushrooms are the highest source of nutrients for these two antioxidants; when the body uses these foods to make energy, it also induces oxidative stress, because in the process some free radicals are produced, and free radicals are often Some oxygen atoms that contain unpaired electrons can induce cellular damage.

By supplementing the body with antioxidants, the body can be protected from damage caused by oxidative stress. Researcher Beelman said that the theory of free radicals on aging has existed for a long time. When we oxidize food to produce energy, it produces some free radicals (by-products), many of which are toxic and have many organisms. An important mechanism that can control free radicals, such as oxidants, but enough free radicals can induce damage to the body, and these injuries are often directly related to a variety of aging diseases, such as cancer, coronary heart disease and Alzheimer's disease.

[8] Can aging stop it?

It is a natural law to live, die, and die, but many people must have thought that with the advancement of science, will there be a way to never grow old? Researchers at the University of Arizona in the United States have brought bad news: mathematically, aging can not be prevented by multicellular organisms like humans.

One of the researchers, University of Arizona professor Joanna Messer said in a statement: "Mathematically, aging is inevitable and completely inevitable. There is no way in logic, theory or mathematics."

Messer and postdoctoral fellow Paul Nelson reported in the new issue of the Proceedings of the National Academy of Sciences that at the cellular level, there are two situations in which people age. On the one hand, most cells form slower and function begins to lose. For example, hair cells stop producing pigments and cause whitening of hair; on the other hand, some cells grow faster and may form cancer cells. When people age to a certain extent, many people will have cancer cells in their bodies, but they will not show cancer.

[9]Nature Supplement: Mayo scientists find that eliminating aging cells in the body can effectively slow down aging

Science fiction writers have imagined what might happen to humanity in the future, and this is becoming a self-testing prophecy. The stories that have appeared in science fiction, such as IVF, satellite, and the Internet, are now a reality. I have to admit that science and technology are constantly developing at a geometric multiple. The famous scientist, the author of "Singularity Approach", Raymond Kozwell, has boldly predicted that the dream of "life and immortality" will eventually be realized.

Although humans cannot escape the fate of death to this day, understanding the mechanism of aging may help prevent or reverse the diseases associated with aging and prolong their healthy life.

After the efforts of scientists, the most important biological process behind aging is uncovered, that is, cell aging, and they found that aging cell accumulation is closely related to chronic diseases in the elderly. Therefore, the elimination of aging cells to delay aging and prevent chronic diseases in the elderly has caused widespread concern among scientists.

Recently, researchers at the Mayo Medical Center in the United States used their "senolytic" drugs to target the eradication of "aging" rat senescent cells and found that they can reduce bone resorption (the process by which osteoclasts break down bone), maintain or increase bone formation, and ultimately It increases bone mass, strengthens bone, and prevents osteoporosis associated with aging. This latest study was published in the recent Nature Medicine.

[10] GeroScience: Limit calorie intake to resist aging!

DOI: 10.1007/s11357-017-9976-8

It has been rumored that reducing the amount of food consumed can reduce the rate of metabolism and prolong life. Until recently, this statement has gradually become a mainstream trend. Many large anti-aging themes have discussed fasting as a scientific content, while Silicon Valley elites have called moderate fasting "biohackers."

In an article recently published in the journal GeroScience, researchers from the University of Oklahoma presented new insights in this area. The article, "Role of DNA methylation in the dietary restriction mediated cellular memory," reveals the underlying mechanism of several benefits of fasting, that is, fasting leads to a decrease in the level of methylation of specific gene promoters, thereby increasing these The level of expression of the gene ultimately has a permanent effect on the memory of the cell.

Of course, drinking anti-aging health care products may help anti-aging, especially the recently discovered nano-platinum anti-aging oral liquid and other products, will increase the anti-aging effect.

Source: Bio Valley